Apicidin-Resistant HA22T Hepatocellular Carcinoma Cells strongly activated the Wnt/\beta-Catenin Signaling Pathway and MMP-2 Expression via the IGF-IR/PI3K/Akt Signaling Pathway Enhancing Cell Metastatic Effect

نویسندگان

  • Cheng-Hong HSIEH
  • Li-Hao CHENG
  • Hsi-Hsien HSU
  • Tsung-Jung HO
  • Chuan-Chou TU
  • Yueh-Min LIN
  • Ming-Cheng CHEN
  • Fuu-Jen TSAI
  • You-Liang HSIEH
  • Chih-Yang HUANG
چکیده

Department of Health and Nutritional Biotechnology, Asia University, Taichung 41354, Taiwan Graduate Institute of Basic Medical Science, China Medical University, Taichung 41354, Taiwan Division of Colorectal Surgery, Mackay Memorial Hospital, Taipei 10449, Taiwan Mackay Medicine, Nursing and Management College, Taipei 11260, Taiwan Chinese Medicine Department, China Medical University Beigang Hospital, Yunlin 65152, Taiwan Division of Chest Medicine, Department of Internal Medicine, Armed Force Taichung General Hospital, Taichung 41152, Taiwan Department of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management College, Taipei 11260, Taiwan Puli Branch, Taichung Veterans General Hospital, Nantou 54552, Taiwan Graduate Institute of Chinese Medical Science, China Medical University, Taichung 40402, Taiwan

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Angiopoietin-like protein 8 (betatrophin) may inhibit hepatocellular carcinoma through suppressing of the Wnt signaling pathway

Objective(s): Hepatocellular carcinoma (HCC) is one of the leading fatal neoplasms and the most common primary liver malignancy worldwide. Peptide hormone ANGPTL8 (betatrophin) may act as an important regulator in HCC development through the Wnt/β-catenin pathway. We aimed to evaluate the effects of recombinant ANGPTL8 on Wnt/β-catenin signaling in human liver carcinom...

متن کامل

The protective effect of propofol on hydrogen peroxide-induced human esophageal carcinoma via blocking the Wnt/β-catenin signaling pathway

Objective(s): To analyze the potential influences of propofol on the oxidative stress of H2O2-induced human esophageal squamous cell carcinoma (ESCC) Eca109 cell through mediating the Wnt/β-catenin signaling pathway.Materials and Methods: Eca109 cells were classified into 5 groups: Control group, H2O2 group, Propofol + H2O2 group, Dkk1 (Dickkopf-1, Wnt/β-catenin pathway antagonist) + H2O2 group...

متن کامل

The Role of Wnt/β-catenin Signaling Pathway in Rat Primordial Germ Cells Reprogramming and Induction into Pluripotent State

 Primordial Germ Cells (PGCs) are unipotent precursors of the gametes. PGCs can give rise to a type of pluripotent stem cells in vitro that are called embryonic germ (EG) cells. PGCs can also acquire such pluripotency in vivo and generate teratomas. Under specific culture conditions, PGCs can be reprogrammed to embryonic germ cells which are capable of expression of key pluripotency marker...

متن کامل

Nanocurcumin-Mediated Down-Regulation of Telomerase Via Stimulating TGFβ1 Signaling Pathway in Hepatocellular Carcinoma Cells

Background: Curcumin, extracted from turmeric, represents enormous potential to serve as an anticancer agent. Telomerase is viewed as a prominent molecular target of curcumin, and transforming growth factor-β1 (TGFβ1) has proven to be a major inhibitory signaling pathway for telomerase activity. In the current study, we aimed to explore suppressive effects of nanocurcumin on telomeras...

متن کامل

Anti-diabetic effect of loganin by inhibiting FOXO1 nuclear translocation via PI3K/Akt signaling pathway in INS-1 cell

Objective(s): JiangTangXiaoKe (JTXK) granule, a Chinese traditional herbal formula, has been clinically used and demonstrated to be beneficial in controlling high glucose and to relieve the symptoms of  Type 2 diabetes mellitus patients for decades. In this study, we explored how loganin, one of the components in JTXK granule, mediated the anti-diabetic effect.Materials and Methods: We generate...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013